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KMID : 1011420180230010001
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Journal of Korean Ophthalmic Optics Society
2018 Volume.23 No. 1 p.1 ~ p.10
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A Study for Physicochemical Properties of the Ophthalmic Medical Devices Containing Phosphorous Group Material
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Cho Seung-Kwon
Park Ji-Hoon
Lim Gyun-Tack
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Abstract
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Purpose: In this study, the physicochemical properties of hydrogel soft contact lenses were investigated by introducing phosphorous materials, which are known as biocompatible components to improve comfort and wettability.
Methods: The homopolymer of PolyHydroxy ethyl methacrylate (PHEMA), methacrylic acid (MA) series (MA and PHEMA) known as ionic groups and copolymers of phosphorus group (PC) and PHEMA were prepared with hydrogel. The applicability of the MP samples composed of PC as the hydrogel contact lens material was evaluated by FT-IR analysis, TGA thermal stability, tensile strength, water content, oxygen Permeability, etc., and the characteristics such as contact angle and protein adsorption amount for evaluating wettability were compared and analyzed.
Results: The copolymerization state of the hydrogel samples was confirmed by FT-IR analysis, and thermal decomposition was analyzed with TGA and the thermal stability was confirmed to be high. Water content was measured by hydrophilization property. When the homopolymer POL samples of PHEMA have a water content of 40% and the MA series samples copolymerized with the ionic component increases to 2.50 mol% (50.46%) and 5.00 mol% (66.68%). The MP samples of phosphorus (PC) was increased as the content of phosphorous was increased (51.41%, 61.03%, 70.84%). The Oxygen permeability (Dk) of the POL samples was 8.22 (Dk × 10?11), and the MA and MP series samples increased in proportion to the water content. The highest oxygen permeability was measured as MP03 sample 27.80 (Dk × 10?11). In order to evaluate the durability of hydrogel contact lenses, specimens were prepared by the films. The MP series samples with high water content were measured very low (0.117 MPa, 0.086 MPa, 0.041 MPa). In this study, The contact angle and the degree of protein adsorption were measured to evaluate the wettability indirectly. Generally, in the samples containing ionic group and phosphorus component, the contact angle was measured lower than that of the POL samples, and the hydrophilic property was stronger and the wetting property was confirmed to be high. In the measurement of the protein adsorption amount of each sample, it was confirmed that the MP series samples containing the phosphorus materials had a decrease in protein adsorption amount as a whole.
Conclusions: When the characteristics of PC material derived from this study are compared with each other by physicochemical analysis, it is considered that it can be applied as an ophthalmic medical device sufficiently. In order to secure more stability after production as a finished product, Biological Evaluation can be added.
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KEYWORD
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Wettability, Phosphorous, Contact angle, Protein absorption
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